2nd INTERNATIONAL CONFERENCE ON APPLICATIONS OF

NEUROIMAGING TO ALCOHOLISM

I C A N A - 2

PROGRAM OUTLINE

January 19 - 20, 2008

Neuroimaging Topics: PET-SPECT, MRI, DTI, MRS, fMRI, Multi-Modal Imaging

Sponsored by: National Institute on Alcohol Abuse and Alcohollism (NIAAA) and

Yale University School of Medicine, Department of Psychiatry (CTNA)

Day 1: Saturday, January 19, 2008

Overviews - ABSTRACTS
John Krystal, Director NIAAA Center for the Translational Neuroscience of Alcoholism (CTNA): Welcome
Ting-Kai Li, Director NIAAA: Imaging in Alcohollism
Adolf Pfefferbaum: Keynote Speaker: Magnetic Resonance Neuroimaging in Alcoholism

PET-SPECT - Chair - Anissa Abi-Dargham - ABSTRACTS
Richard Carson: The future of high resolution PET imaging
Mack Laurelle: Imaging receptor trafficking
Julie Staley: Delineating the regulatory effects of alcohol drinking and tabacco smokiing on brain nicotinic acetylcholine receptor availability
David Nutt: Imaging the GABA-A benzodiazepine system in alcohol dependence
Kelly Cosgrove: SPECT imaging of GABA-A, benzodiazepine receptors during acute and prolonged withdrawal from chronic alcohol consumption in nonhuman primates
Gary Wand: Treatment implications of opiate receptor binding-PET
Diana Martinez: PET imaging of the serotonin transporters and 5HT-1A receptors in alcohol dependence
PET - Posters - ABSTRACTS
Panayotis Thanos: In-vivo changes in brain glucose metabolism and dopamine D2 receptor availability in response to actue ethanol binge drinking in rats
Anderson Mon: Comparison of cerebral perfusion changes in non-smoking and smoking recovering alcoholics
Kelly Cosgrove: [123I]Beta-CIT imaging of DAT and SERT availability in heavy alcohol drinkers during acute withdrawal
Irina Esterlis: [123I]Iomazenil SPECT imaging of benzodiazepine receptor availability in long term sober alcohol dependent subjects
Markus Storvik: Serotonin receptors and transporters in alcohol dependence (measured with autoradiography)

MRI/DTI/MRS - Chair - Graeme Mason - ABSTRACTS
Brian Schweinsburg: Exploring the relationship between white matter fiber integrity and computational morphometry of gray matter across a range of alcohol exposure
Dieter Meyerhoff: MRI and DTI guided spectroscopic imaging in alcoholism
Graeme Mason: Acute effects of nicotine and ethanol on braiin GABA
Elfar Adalsteinsson: In vivo MR approaches for tracking the effects of scheduled alcohol exposure on brain structure and chemistry in a rodent model
Armin Biller: Early brain recovery associated with abstinence from alcohollism
MRI/DTI/MRS POSTERS - ABSTRACTS
Joanna Jacobus: Altered brain metabolism in alcoholic individuals with self-reported history of withdrawal seizures
Karen Hanson: Hippocampal volumes in adolescents with and without a family history of alcoholism
Graham Flory: Regional variability in the non-human primate brain ethanol magnetic resonance spectrum
Stefan Gazdzinski: Are treated alcoholics representative of the entire population with alcohol use disorders? - A brain magnetic resonance study
Timothy Durazzo: Magnetic resonance derived and neuropsychological predictors of relapse in treatment seeking alcoholics
Scott Parnell: Early gestational ethanol exposure in mice results in brain abnormalities as demonstrated by high-resolution MRI
Dawn Thatcher: Prefrontal white matter organization, executive cognitive functioning and alcohol use disorders in adolescents
Timothy McQueeny: Altered white matter fiber integrity in adolescent binge drinkers

fMRI - Chair - Edith Sullivan - ABSTRACTS
Edith Sullivan: Imaging alcoholism through the ages
Gregory Brown: Measuring cerebral blood flow with arterial spin labeling: Brain activation and hemodynamic confounds
Marlene Oscar-Berman: Anatomical deficits in alcoholism
fMRI POSTERS - ABSTRACTS
Young-Chul Jung: Defects in shifting performance startegy of alcoholics: Functional connectivity analysis of anterior cinculate cortex
Shashwath Meda: Alcohol dose effects on brain circuits during simulated driving: An fMRI study
Chiang-shan Ray Li: Cognitive control and alcohol dependence - A functional magnetic resonance imaging (fMRI) study of the stop signal task
Ryan Trim: Alcohol effects on brain activation in matched low and high level responders to alcohol
Andria Norman: An fMRI study of adolescent inhibitory processing prior to the initiation of substance use
Claudia Padula: Spatial working memory in adolescent binge drinkers: An fMRI study
Alecia Schweinsburg: Adolescent binge drinkers show altered fMRI response during verbal encoding
Suchismita Ray: fMRI bold response to emotional, alcohol, marijuana and drug related picture cues in mandated college students
Ashley Smith: Limbic system activation by rewards and losses in detoxified alcoholics: Anticipation, receipt and frustration
Jodi Gilman: Why we drink alcohol: Striatal activation to intravenous alcohol administration and its modulation by emotionally affective stimuli
Megan Davis: Cognitive and emotional processing of affective stimuli in alcohol dependent patients and healthy controls
Allyssa Allen: Effect of alcohol on performance on visual oddball task: An fMRI study
Beth M. Turner: Neural circuitry underlying the effects of alcohol on impulsivity
Andre Thomas: Anticipation of rewards: Activation differences iin current and former cocaine users using a monetary incentive delay task
Gregory Book: Reward processing in social competitive task in subjects with familial history of alcoholism
Melissa Andrews: Differences in reward circuit activation in people with a family history of alcoholism

Day 2: Sunday, January 20, 2008

Multi-Modal Imaging: Stratium and Reward - Chair - Andreas Heinz - ABSTRACTS
Anne Lingford-Hughes: The opiod sysem in alcohol dependence
Derik Hermann: Blockade of cue-induced brain activation of abstinent alcoholics by a single adminstration of amisulpride as measured by fMRI
Daniel Hommer: Risk, expectation, work and reward: The plot get more complicated
Ahmad Hariri: Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity
Godfrey Pearlson: Reward circuit abnormalities and family history of alcoholism: Comparison to psychostimulant abusers. Is impulsivity at the root of the problem?
Andreas Heinz: Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics
Michael Smolka: Effect of acamprosate and naltrexone on fMRI bold response to alcohol related stimuli
Anissa Abi-Dargham: Imaging dopamine release in at risk subjects for alcoholism: New probes and new challenges
Dean Wong: In vivo(DA) PET measures in healthy adults with a family history of alcoholism
David Kareken: Ventral striatal change in dopamine as a function of alcohol, alcohol cues and expectations

Brain Development Toward Addiction - Chair - Terry Jernigan- ABSTRACTS
Rebecca Jones: Functional development of reward circuitry
Elizabeth Sowell: Brain imaging in fetal alcohol spectrum disorders
Susan Tapert: Brain function in adolescent heavy drinkers
Jose Javier Miguel-Hidago: Glial neuropathology of alcolism in the prefrontal cortex
Shirley Hill: Volumetric differences in cerebellum, amygdala and oritofrontal cortex in association with susceptibility for alcohol dependence
Bernice Porjesz: Neural oscillations and genes involved in risk for alcohol dependence and related disorders

1st INTERNATIONAL CONFERENCE ON APPLICATIONS OF

NEUROIMAGING TO ALCOHOLISM

I C A N A - 1

PROGRAM OUTLINE

January 17-19, 2004

Neuroimaging Topics: MRI, DTI, MRS, fMRI, PET/SPECT, Molecular Neuroimaging

Sponsored by: National Institute on Alcohol Abuse and Alcohollism (NIAAA) and

Yale University School of Medicine, Department of Psychiatry (CTNA)

Day 1: Saturday, January 17, 2004

Overviews - ABSTRACTS (click for TK Li slides)
T. K. Li, Director NIAAA: Genetic and evironmental influences on alcohol drinking behavior
Adolf Pfefferbaum: Keynote Speaker: Synthesis of neuroimaging applications in alcoholism
David Goldman: Imaging genetics and brain function

MRI/DTI - Chair - Daniel Mathalon - ABSTRACTS
Arthur Toga: Mapping morphological concomitants to brain disease
Derek Jones: Diffusion Tensor MRI - what can it tell us about white matter in alcoholism? (Slides)
Hannu Aronen: Volumetric studies in alcoholism and psychopathylogy: A focus on medial temporal lobe structures (Slides)
Daniel Hommer: Brain growth and shrinkage (Slides)
Terry Jernigan: Neuroanatomical effects of alcohol exposure in development and adulthood (Slides)
MRI POSTERS - ABSTRACTS
EA DeBruin: Possible brain damage in social drinkers
Stefan Gazdzinski: Rates of recovery of total brain tissue volume during abstinence

MRS - Chair - Graeme Mason - ABSTRACTS
Graeme Mason: Methodology of magnetic resonance spectroscopy (Slides)
Martin Bendszus: 1H MR spectroscopy and MR morphometry in early sobriety: Correlation with neuropsychological data (Slides)
Hoby Hetherington: Alcohol transport and MRS visibility in the brain (Slides)
Brian Ross: Direct or indirect? Distinguishing hepatic from alcoholic encephalopathy (Slides)
Dieter Meyerhoff: Brain spectroscopic imaging, morphometry and cognition in recovering alcoholics and active heavy drinkers (Slides)
Michael Taylor: Brain abnormalities in chronic adult alcoholics measured with proton MR spectroscopy (Slides)
MRS - POSTERS - ABSTRACTS
Bryan Schweinsburg: Neurochemical correlates of blood oxygen level dependent signal changes in abstinent alcoholics

Day 2: Sunday, January 18, 2004

Stephanie O'Malley: Introduction
David Goldman: Imaging genetics and brain function

fMRI - Chair - Daniel Hommer - ABSTRACTS
Edith Sullivan: Executive cognitive function in alcoholism: Insight from fMRI (Slides)
Daniel Mathalon: Automatic processing of alcohol cues in chronic alcoholism: ERP and fMRI
Hugh Myrick: Role of functional imaging in the assessment of craving for alcohol (Slides)
Susan Tapert: fMRI studies in adolescents with alcohol use disorders (Slides)
Daniel Hommer: Motivation in alcoholism (Slides)
fMRI -Posters - ABSTRACTS
Valerie Cestone Barlett: Neural response to a visual working memory fMRI task in adolescents with comorbid alcohol use disorder and conduct disorder
Lisa Caldwell: Neural response to working memory in male and female teens with alcohol use disorders
Vince Calhoun: Intoxication effects on fMRI studies of simulated driving: ICA reveals disruption in synchronous networks
Judith Ford: A method to assess speed of hemodynamic response in alcoholism
Nicole Giuliani: Alcohol versus marinol intoxiction effects on visual perception
Karyn Groth: Visual attention and functional neuroimaging
David Kareken: Mesolimbic response to alcohol olfactory cues in high risk drinkers
Carmen Pulido: Drinking characteristics correlate with bold response during a visual working memory task
Alecia Schweinsburg: fMRI response differences between aldolescents and adults with alcohol use disorders
Michael Smolka: Emotional valence of alcohol associated stimuli and cue-induced bold activation
Jana Wrase: Relapse and gender specific activation in the striatum in alcohol dependent patients

PET/SPECT - Chair - Anissa Abi-Dargham - ABSTRACTS
Mark Laruelle: Molecular imaging of the brain with PET
Julie Staley: Delineating the neurochemical effects of tobacco smoking from alcohol drinking (Slides)
Matthias Reimold: µ-opiate receptors in alcoholics, results from a [11C] carfentanil-PET study (Slides)
Andreas Heinz: Brain imaging studies of the reward system in alcoholism (Slides)
Diana Martinez: Measurement of D2 receptors in striatal substructures in alcohol dependence
Dean Wong: Dopamine imaging, stress and neuroendocrine changes in alcoholics (Slides)
Michael Soyka: Effects of dextrometorphan, alcohol and placebo on brain glucose metabolism (Slides)
Wendol Williams: Acute plasma tryptophan depletion on serontonin receptor occupancy
Peter Talbot: Synaptic 5-HT concentration, [11C]DASB, and rapid tryptophan depletion method
PET - Posters - ABSTRACTS
Kelly Cosgrove: [123I]5-IA-85830 Spect imaging of nAChR in nonhuman primate brain: Pharmacological specificity and effects of chronic nicotine administration
Lawrence Kegeles: Benzodiazepine receptor agonist PET radioligand, [11C]triazolam: Evaluation in baboons
Zizhong Li: Direct and non-invasive study of ethanol pharmacokinetics in baboon using PET and carbon-11 and deuterium labeled ethanol
Christian Schutz: Opioid receptor binding differences between alcohol dependent subjects and health controls before and 4 weeks into abstinence

Day 3: Monday, January 19, 2004

Molecular Imaging - Chair - Douglas Rothman - ABSTRACTS
Kevin Behar: NMR: glutamate-GABA cycle and GABA synthesis regulation in rodents (Slides)
Kathleen Grant: Imaging changes in monkey brain following ethanol self-administration (Slides)
Anne Lingford-Hughes: Imaging GABA-A and opioid receptors in alcoholism (Slides)
David Nutt: Imaging of activation to alcohol cues and GABA-A receptor function in alcoholism (Slides)
James Frost: PET Imaging of the brain opioid system: focus on addiction
Jari Tiihonen: Whole-hemisphere autoradiography in alcoholism research (Slides)
Karl Mann: Neuroimaging in alcoholism: what can we learn from MR-spectroscopy (Slides)
Raymond Anton: Neurocircuitry of reward and addiction: what we know and what we need to learn (Slides)